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Nutrients. 2018 Jan 23;10(2). pii: E112. doi: 10.3390/nu10020112.

Coffee Intake Decreases Risk of Postmenopausal Breast Cancer: A Dose-Response Meta-Analysis on Prospective Cohort Studies.

Author information

1
The Research Centre on Public Health, University Milano-Bicocca, 20900 Monza, Italy. alessandra.lafranconi@unimib.it.
2
Department of International Health, FHML, CAPHRI, Maastricht University, 6229 Maastricht, The Netherlands. alessandra.lafranconi@unimib.it.
3
Department of Epidemiology and Population Studies, Jagiellonian University Medical College, 31008 Krakow, Poland. agnieszka.micek@uj.edu.pl.
4
Scientific Directorate, National Cancer Institute-IRCCS, 33081 Aviano, Italy. pdepaoli@cro.it.
5
Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori-IRCCS-"Fondazione G. Pascale", 80131 Naples, Italy. s.bimonte@istitutotumori.na.it.
6
Department of Biology and Biotechnology (DBB) "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. paola.rossi@unipv.it.
7
Department of Abdominal Oncology, National Cancer Institute, IRCCS-Foundation G. Pascale, 80131 Naples, Italy. quagliariello.enzo@gmail.com.
8
Department of Medical Oncology, National Cancer Institute-IRCCS, 33081 Aviano, Italy. mberretta@cro.it.

Abstract

Aim: A dose-response meta-analysis was conducted in order to summarize the evidence from prospective cohort studies regarding the association between coffee intake and breast cancer risk. Methods: A systematic search was performed in electronic databases up to March 2017 to identify relevant studies; risk estimates were retrieved from the studies and linear and non-linear dose-response analysis modelled by restricted cubic splines was conducted. A stratified and subgroup analysis by menopausal and estrogen/progesterone receptor (ER/PR) status, smoking status and body mass index (BMI) were performed in order to detect potential confounders. Results: A total of 21 prospective studies were selected either for dose-response, the highest versus lowest category of consumption or subgroup analysis. The dose-response analysis of 13 prospective studies showed no significant association between coffee consumption and breast cancer risk in the non-linear model. However, an inverse relationship has been found when the analysis was restricted to post-menopausal women. Consumption of four cups of coffee per day was associated with a 10% reduction in postmenopausal cancer risk (relative risk, RR 0.90; 95% confidence interval, CI 0.82 to 0.99). Subgroup analyses showed consistent results for all potential confounding factors examined. Conclusions: Findings from this meta-analysis may support the hypothesis that coffee consumption is associated with decreased risk of postmenopausal breast cancer.

KEYWORDS:

breast cancer; caffeine; coffee; dose-response; meta-analysis; postmenopausal; receptor

PMID:
29360766
PMCID:
PMC5852688
DOI:
10.3390/nu10020112
[Indexed for MEDLINE]
Free PMC Article

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