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Int J Dev Neurosci. 2018 May;66:37-44. doi: 10.1016/j.ijdevneu.2018.01.003.

Pilot study of EEG in neonates born to mothers with gestational diabetes mellitus.

Author information

1
Research Center on Aging, Centre intégré de santé et services sociaux de l'Estrie-Centre hospitalier de l'Université de Sherbrooke, 1036 Belvédère Sud, Sherbrooke, Quebec, J1H 4C4, Canada; Department of Physiology, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC, Canada.
2
Research Center on Aging, Centre intégré de santé et services sociaux de l'Estrie-Centre hospitalier de l'Université de Sherbrooke, 1036 Belvédère Sud, Sherbrooke, Quebec, J1H 4C4, Canada.
3
Department of Physiology, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada; Department of Medicine, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada; Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada.
4
Department of Medicine, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada; Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada.
5
Department of Medicine, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada.
6
Department of Medicine, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada; Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada. Electronic address: kevin.whittingstall@usherbrooke.ca.
7
Research Center on Aging, Centre intégré de santé et services sociaux de l'Estrie-Centre hospitalier de l'Université de Sherbrooke, 1036 Belvédère Sud, Sherbrooke, Quebec, J1H 4C4, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC, Canada; Department of Medicine, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada. Electronic address: Melanie.Plourde2@usherbrooke.ca.

Abstract

BACKGROUND:

The goal was to evaluate whether there was neurodevelopmental deficits in newborns born to mothers with gestational diabetes mellitus (GDM) compared to control newborns born to healthy mothers.

METHODS:

Forty-six pregnant women (21 controls and 25 GDM) were recruited. Electroencephalogram (EEG) was recorded in the newborns within 48 h after birth. The EEG signal was quantitatively analyzed using power spectral density (PSD); coherence between hemispheres was calculated in paired channels of frontal, temporal, central and occipital regions.

RESULTS:

The left centro-occipital PSD in control newborns was 12% higher than in GDM newborns (p = 0.036) but was not significant after adjustment for gestational age. While coherence was higher in the frontal regions compared to the occipital regions (p < 0.001), there was no difference between the groups for the fronto-temporal, frontal-central, centro-occipital and tempo-occipital regions.

CONCLUSION:

Our results support that EEG differences between groups were mainly modified by gestational age and less by GDM status of the mothers. However, there is a need to confirm this result with a higher number of mother-newborns. Quantitative EEG in GDM newborns within 48 h after birth is feasible. This study emphasizes the importance of controlling blood glucose during GDM to protect infant brain development.

KEYWORDS:

Electroencephalogram; Gestational diabetes mellitus; Glucose control; Newborn; Power spectral density

PMID:
29360555
DOI:
10.1016/j.ijdevneu.2018.01.003
[Indexed for MEDLINE]

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