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Braz J Infect Dis. 2018 Jan - Feb;22(1):24-29. doi: 10.1016/j.bjid.2017.12.002. Epub 2018 Jan 19.

Retrospective evaluation of the clinical characteristics associated with Corynebacterium species bacteremia.

Author information

1
Nihon University School of Medicine, Department of Internal Medicine, Division of General Medicine, Tokyo, Japan. Electronic address: yanai.mitsuru@nihon-u.ac.jp.
2
Nihon University School of Medicine, Department of Internal Medicine, Division of General Medicine, Tokyo, Japan.
3
Nihon University School of Medicine, Department of Pathology and Mircobiology, Division of Laboratory Medicine, Tokyo, Japan.

Abstract

OBJECTIVES:

Corynebacterium spp. are becoming recognized as pathogens that potentially cause various infections. We aimed to evaluate the clinical characteristics associated with Corynebacterium spp. bacteremia.

PATIENTS AND METHODS:

We retrospectively reviewed the medical records of all adult patients who had positive blood cultures for Corynebacterium spp. in a single university hospital between January 2014 and December 2016. Patients were divided into a bacteremia group and a contamination group based on microbiological test results and clinical characteristics. Patients' characteristics, antimicrobial susceptibility of isolated species, antimicrobials administered, and patient outcomes were evaluated.

RESULTS:

Corynebacterium spp. were isolated from blood samples of 63 patients; Corynebacterium striatum was the predominant isolate. Twenty-eight patients were determined to have bacteremia. Younger age (p=0.023), shorter time to positivity (p=0.006), longer hospital stay (p=0.009), and presence of an indwelling vascular catheter (p=0.002) were observed more often in the bacteremia group compared to the contamination group. The source of infection in most patients with bacteremia was an intravenous catheter. All tested strains were susceptible to vancomycin. Four of the 27 patients with bacteremia died, despite administration of appropriate antimicrobial therapy.

CONCLUSIONS:

We found that younger age, shorter time to positivity, and presence of an indwelling catheter were related to bacteremia caused by Corynebacterium spp. Appropriate antimicrobials should be administered once Corynebacterium spp. are isolated from the blood and bacteremia is suspected.

KEYWORDS:

Blood culture; Bloodstream infection; Contamination; Corynebacterium species

PMID:
29360429
DOI:
10.1016/j.bjid.2017.12.002
[Indexed for MEDLINE]
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