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Cytoskeleton (Hoboken). 2018 Mar;75(3):87-102. doi: 10.1002/cm.21434. Epub 2018 Feb 8.

New dimensions of asymmetric division in vertebrates.

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Department of Molecular, Cell and Cancer Biology University of Massachusetts Medical School, Worcester, Massachusetts.
Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, New York, 13210.
Program in Molecular Medicine University of Massachusetts Medical School, Worcester, Massachusetts.


Traditionally, we imagine that cell division gives rise to two identical daughter cells. Nevertheless, all cell divisions, to some degree, display asymmetry. Asymmetric cell division is defined as the generation of two daughter cells with different physical content and/or developmental potential. Several organelles and cellular components including the centrosome, non-coding RNA, chromatin, and recycling endosomes are involved in the process of asymmetric cell division. Disruption of this important process is known to induce profound defects in development, the immune response, regeneration of tissues, aging, and cancer. Here, we discuss recent advances that expand our understanding of the mechanisms and consequences of asymmetric cell division in vertebrate organisms.


T cells; aging; asymmetric division; cancer; cell division; mitosis; non-coding RNA; regeneration; stem cell

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