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Transpl Infect Dis. 2018 Apr;20(2):e12836. doi: 10.1111/tid.12836. Epub 2018 Feb 12.

A cluster of donor-derived Cryptococcus neoformans infection affecting lung, liver, and kidney transplant recipients: Case report and review of literature.

Author information

1
Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA.
2
Department of Medicine, Division of Infectious Diseases, University of Florida School of Medicine, Gainesville, FL, USA.
3
Department of Medicine, Division of Nephrology, University of Miami Miller School of Medicine, Miami, FL, USA.
4
Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

Abstract

Donor-derived infections (DDIs) are a very rare but potentially devastating complication of solid organ transplantation. Here we present a cluster of proven donor-derived cryptococcal infection in the kidney, liver, and lung recipients from a single donor. Remarkably, the onset of illness in the kidney and liver recipients occurred more than 8-12 weeks after transplantation, which is beyond the incubation period previously reported for donor-derived cryptococcosis. DDI should always be considered in the differential diagnosis of transplant recipients admitted with febrile illness, even when presenting beyond the first month post-transplant. Communication between reference laboratories, transplant centers, and organ procurement organizations is critical to improve outcomes.

KEYWORDS:

Cryptococcus ; donor-derived infection; solid organ transplant

PMID:
29359837
DOI:
10.1111/tid.12836
[Indexed for MEDLINE]

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