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Biomed Opt Express. 2017 Dec 4;9(1):41-54. doi: 10.1364/BOE.9.000041. eCollection 2018 Jan 1.

Time-resolved near infrared light propagation using frequency domain superposition.

Author information

1
School of Computer Science, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
2
ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain.
3
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

Abstract

Time-resolved temporal point spread function (TPSF) measurement of near infrared spectroscopic (NIRS) data allows the estimation of absorption and reduced scattering properties of biological tissues. Such analysis requires an iterative calculation of the theoretical TPSF curve using mathematical and computational models of the domain being imaged which are computationally complex and expensive. In this work, an efficient methodology for representing the TPSF data using a superposition of cosines calculated in frequency domain is presented. The proposed method is outlined and tested on finite element realistic models of the human neck and head. Using an adult head model containing ~140k nodes, the TPSF calculation at each node for one source is accelerated from 3.11 s to 1.29 s within an error limit of ± 5% related to the time domain calculation method.

KEYWORDS:

(170.3660) Light propagation in tissues; (170.5270) Photon density waves

Conflict of interest statement

The authors declare that there are no conflicts of interest related to this article. LUCA project involves industrial collaboration and, as such, potential conflicts of interest are being monitoring by relevant institutional bodies. None has been identified to date.

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