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World J Hepatol. 2017 Dec 28;9(36):1367-1371. doi: 10.4254/wjh.v9.i36.1367.

Autoimmune hepatitis in the setting of human immunodeficiency virus infection: A case series.

Author information

1
Division of Gastroenterology and Hepatology, the Brooklyn Hospital Center, Academic Affiliate of the Icahn School of Medicine at Mount Sinai, Clinical Affiliate of the Mount Sinai Hospital, Brooklyn, NY 11201, United States.
2
Division of Gastroenterology and Hepatology, the Brooklyn Hospital Center, Academic Affiliate of the Icahn School of Medicine at Mount Sinai, Clinical Affiliate of the Mount Sinai Hospital, Brooklyn, NY 11201, United States. dramai@sgu.edu.
3
Division of Advanced Endoscopy, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.

Abstract

Liver injury in the setting of human immunodeficiency virus (HIV) infection is more commonly attributed to viral hepatitis or highly active antiretroviral treatment (HAART) toxicity. The severity of liver injury is an important cause of morbidity and mortality. The emergence of autoimmune diseases, particularly autoimmune hepatitis (AIH) in the setting of HIV infection, is rare. Previous reports indicate that elevated liver enzymes are a common denominator amongst these patients. We present two patients with HIV infection, on HAART, with virological suppression. Both patients presented with elevated liver enzymes, and following liver biopsies, were diagnosed with AIH. The clinical course of these patients underscore the therapeutic value of corticosteroids, and in some cases, addition of immunosuppression for AIH treatment.

KEYWORDS:

Autoimmune hepatitis; Autoimmunity; Human immunodeficiency virus; Immunosuppression; Liver biopsy

Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest or financial relationships to disclose.

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