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Nat Commun. 2018 Jan 22;9(1):306. doi: 10.1038/s41467-017-02719-2.

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner.

Author information

1
The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.
2
Department of Anatomy & Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia.
3
Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.
4
Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
5
Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC, 3010, Australia.
6
Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health and Science University, Portland, OR, 97239, USA.
7
Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
8
Schools of Biomedical Sciences, The University of Queensland, St Lucia, QLD, 4072, Australia.
9
Melbourne Neuroscience Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
10
The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia. tobias.merson@monash.edu.
11
Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia. tobias.merson@monash.edu.
12
Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia. tobias.merson@monash.edu.
13
The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia. emeryb@ohsu.edu.
14
Department of Anatomy & Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia. emeryb@ohsu.edu.
15
Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health and Science University, Portland, OR, 97239, USA. emeryb@ohsu.edu.

Abstract

Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which neuronal activity is capable of regulating myelination at the individual axon level is unclear. Here we demonstrate that stimulation of somatosensory axons in the mouse brain increases proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) within the underlying white matter. Stimulated axons display an increased probability of being myelinated compared to neighboring non-stimulated axons, in addition to being ensheathed with thicker myelin. Conversely, attenuating neuronal firing reduces axonal myelination in a selective activity-dependent manner. Our findings reveal that the process of selecting axons for myelination is strongly influenced by the relative activity of individual axons within a population. These observed cellular changes are consistent with the emerging concept that adaptive myelination is a key mechanism for the fine-tuning of neuronal circuitry in the mammalian CNS.

PMID:
29358753
PMCID:
PMC5778130
DOI:
10.1038/s41467-017-02719-2
[Indexed for MEDLINE]
Free PMC Article

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