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Nat Genet. 2018 Feb;50(2):297-306. doi: 10.1038/s41588-018-0039-6. Epub 2018 Jan 22.

Bph6 encodes an exocyst-localized protein and confers broad resistance to planthoppers in rice.

Author information

1
State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, China.
2
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
3
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China.
4
BGI-Shenzhen, Shenzhen, China.
5
State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, China. bodu@whu.edu.cn.
6
State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, China. gche@whu.edu.cn.

Abstract

The brown planthopper (BPH) and white-backed planthopper (WBPH) are the most destructive insect pests of rice, and they pose serious threats to rice production throughout Asia. Thus, there are urgent needs to identify resistance-conferring genes and to breed planthopper-resistant rice varieties. Here we report the map-based cloning and functional analysis of Bph6, a gene that confers resistance to planthoppers in rice. Bph6 encodes a previously uncharacterized protein that localizes to exocysts and interacts with the exocyst subunit OsEXO70E1. Bph6 expression increases exocytosis and participates in cell wall maintenance and reinforcement. A coordinated cytokinin, salicylic acid and jasmonic acid signaling pathway is activated in Bph6-carrying plants, which display broad resistance to all tested BPH biotypes and to WBPH without sacrificing yield, as these plants were found to maintain a high level of performance in a field that was heavily infested with BPH. Our results suggest that a superior resistance gene that evolved long ago in a region where planthoppers are found year round could be very valuable for controlling agricultural insect pests.

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PMID:
29358653
DOI:
10.1038/s41588-018-0039-6
[Indexed for MEDLINE]

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