1. Am J Med. 2018 Jun;131(6):693-701. doi: 10.1016/j.amjmed.2017.12.027. Epub 2018
Mar 5.

Oxygen Therapy in Patients with Acute Myocardial Infarction: A Systemic Review
and Meta-Analysis.

Abuzaid A(1), Fabrizio C(2), Felpel K(2), Al Ashry HS(3), Ranjan P(2), Elbadawi
A(4), Mohamed AH(4), Barssoum K(4), Elgendy IY(5).

Author information: 
(1)Department of Cardiovascular Medicine, Sidney Kimmel Medical College at Thomas
Jefferson University/Christiana Care Health System, Newark, Del. Electronic
address: aabuzaidmd@gmail.com.
(2)Department of Cardiovascular Medicine, Sidney Kimmel Medical College at Thomas
Jefferson University/Christiana Care Health System, Newark, Del.
(3)Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical
University of South Carolina, Charleston.
(4)Department of Medicine, Rochester General Hospital, Rochester, NY.
(5)Department of Medicine, Division of Cardiovascular Medicine, University of
Florida, Gainesville.

OBJECTIVE: Oxygen therapy is frequently used for patients with acute myocardial
infarction. The aim of this study is to perform a systematic review and
meta-analysis to compare the outcomes of oxygen therapy versus no oxygen therapy 
in post-acute myocardial infarction settings.
METHODS: A systematic search of electronic databases was conducted for randomized
studies, which reported cardiovascular events in oxygen versus no oxygen therapy.
The evaluated outcomes were all-cause mortality, recurrent coronary events
(ischemia or myocardial infarction), heart failure, and arrhythmias.
Summary-adjusted risk ratios (RRs) were calculated by the random effects
DerSimonian and Laird model. The risk of bias of the included studies was
assessed by Cochrane scale.
RESULTS: Our meta-analysis included a total of 7 studies with 3842 patients who
received oxygen therapy and 3860 patients without oxygen therapy. Oxygen therapy 
did not decrease the risk of all-cause mortality (pooled RR, 0.99; 95% confidence
interval [CI], 0.81-1.21; P = .43), recurrent ischemia or myocardial infarction
(pooled RR, 1.19; 95% CI, 0.95-1.48; P = .75), heart failure (pooled RR, 0.94;
95% CI, 0.61-1.45; P = .348), and occurrence of arrhythmia events (pooled RR,
1.01; 95% CI, 0.85-1.2; P = .233) compared with the no oxygen arm.
CONCLUSIONS: This meta-analysis confirms the lack of benefit of routine oxygen
therapy in patients with acute myocardial infarction with normal oxygen
saturation levels.

Copyright © 2018 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.amjmed.2017.12.027 
PMID: 29355510