Format

Send to

Choose Destination
Diabetologia. 2018 Apr;61(4):770-774. doi: 10.1007/s00125-018-4546-x. Epub 2018 Jan 21.

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource.

Author information

1
Department of Clinical and Experimental Medicine and University Hospital, University of Pisa, via Paradisa 2, 56121, Pisa, Italy. piero.marchetti@med.unipi.it.
2
Department of Clinical and Experimental Medicine and University Hospital, University of Pisa, via Paradisa 2, 56121, Pisa, Italy.

Abstract

Direct in vivo assessment of pancreatic islet-cells for the study of the pathophysiology of diabetes in humans is hampered by anatomical and technological hurdles. To date, most of the information that has been generated is derived from histological studies performed on pancreatic tissue from autopsy, surgery, in vivo biopsy or organ donation. Each approach has its advantages and disadvantages (as summarised in this commentary); however, in this edition of Diabetologia, Kusmartseva et al ( https://doi.org/10.1007/s00125-017-4494-x ) provide further evidence to support the use of organ donor pancreases for the study of human diabetes. They show that length of terminal hospitalisation of organ donors prior to death does not seem to influence the frequency of inflammatory cells infiltrating the pancreas and the replication of beta cells. These findings are reassuring, demonstrating the reliability of this precious and valuable resource for human islet cells research.

KEYWORDS:

Autoptic samples; Beta cells; Islet cells; Organ donors; Pancreatectomy; Pancreatic biopsies

PMID:
29354869
DOI:
10.1007/s00125-018-4546-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center