Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants

Mark D Pankau; Dalton Wamalwa; Sarah Benki-Nugent; Kenneth Tapia; Evelyn Ngugi; Agnes Langat; Vincent Otieno; Helen Moraa; Elizabeth Maleche-Obimbo; Julie Overbaugh; Grace C John-Stewart; Dara A Lehman

doi:10.1093/ofid/ofx268

Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants

Open Forum Infect Dis. 2017 Dec 9;5(1):ofx268. doi: 10.1093/ofid/ofx268. eCollection 2018 Jan.

Authors

Mark D Pankau^{1

2}, Dalton Wamalwa³, Sarah Benki-Nugent², Kenneth Tapia², Evelyn Ngugi³, Agnes Langat³, Vincent Otieno³, Helen Moraa³, Elizabeth Maleche-Obimbo³, Julie Overbaugh^{1

4}, Grace C John-Stewart^{2

5

6

7}, Dara A Lehman^{1

2}

Affiliations

¹ Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
² Department of Global Health, University of Washington, Seattle, Washington.
³ Department of Paediatrics, University of Nairobi, Nairobi, Kenya.
⁴ Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
⁵ Department of Medicine, University of Washington, Seattle, Washington.
⁶ Department of Pediatrics, University of Washington, Seattle, Washington.
⁷ Department of Epidemiology, University of Washington, Seattle, Washington.

Abstract

We compared change in HIV reservoir DNA following continued antiretroviral therapy (ART) vs short treatment interruption (TI) in early ART-treated Kenyan infants. While HIV DNA in the reservoir decayed with continued ART, HIV DNA levels were similar to pre-TI HIV DNA reservoir levels in most children after short TI.

Keywords: HIV DNA; antiretroviral therapy; infants; reservoir; treatment interruption.

Abstract

Grants and funding