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Br J Nutr. 2018 Mar;119(6):610-619. doi: 10.1017/S000711451700366X. Epub 2018 Jan 21.

Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children.

Author information

1
1Centre of Excellence for Nutrition,North-West University,Potchefstroom 2520,South Africa.
2
2Non-Communicable Diseases Research Unit,South African Medical Research Council,Cape Town 7505,South Africa.
3
4Laboratory of Human Nutrition,Institute of Food, Nutrition and Health,ETH Zurich,8092 Zurich,Switzerland.

Abstract

Zn status may affect fatty acid (FA) metabolism because it acts as a cofactor in FA desaturase and elongase enzymes. Zn supplementation affects the FA desaturases of Zn-deficient rats, but whether this occurs in humans is unclear. We evaluated the associations between baseline plasma Zn (PZn) concentration and plasma total phospholipid FA composition, as well as the effect of daily consumption of Zn-fortified water on FA status in Beninese children. A 20-week, double-blind randomised controlled trial was conducted in 186 school age children. The children were randomly assigned to receive a daily portion of Zn-fortified, filtered water delivering on average 2·8 mg Zn/d or non-fortified filtered water. Plasma total phospholipid FA composition was determined using capillary GLC and PZn concentrations by atomic absorption spectrometry. At baseline, PZn correlated positively with dihomo-γ-linolenic acid (DGLA, r 0·182; P=0·024) and the DGLA:linoleic acid (LA) ratio (r 0·293; P<0·000), and negatively with LA (r -0·211; P=0·009) and the arachidonic acid:DGLA ratio (r -0·170; P=0·036). With the intervention, Zn fortification increased nervonic acid (B: 0·109; 95 % CI 0·001, 0·218) in all children (n 186) and more so in children who were Zn-deficient (n 60) at baseline (B: 0·230; 95 % CI 0·023, 0·488). In conclusion, in this study, Zn-fortified filtered water prevented the reduction of nervonic acid composition in the plasma total phospholipids of children, and this effect was stronger in Zn-deficient children. Thus, Zn status may play an important role in FA desaturation and/or elongation.

KEYWORDS:

AA arachidonic acid; AGP α1-acid glycoprotein; CRP C-reactive protein; DGLA dihomo-γ-linolenic acid; FA fatty acids; FAME fatty acid methyl esters; IQR interquartile range; LA linoleic acid; LCPUFA long-chain PUFA; PZn plasma Zn; Fatty acid; Fatty acid desaturase; Plasma zinc; Zinc fortification

PMID:
29352828
DOI:
10.1017/S000711451700366X
[Indexed for MEDLINE]

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