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Sci Rep. 2018 Jan 19;8(1):1195. doi: 10.1038/s41598-018-19480-1.

Handheld magnetic probe with permanent magnet and Hall sensor for identifying sentinel lymph nodes in breast cancer patients.

Author information

1
Graduate School of Engineering, The University of Tokyo, Tokyo, 113-0032, Japan. sekino@bee.t.u-tokyo.ac.jp.
2
Graduate School of Engineering, The University of Tokyo, Tokyo, 113-0032, Japan. kuwahata@bee.t.u-tokyo.ac.jp.
3
Graduate School of Engineering, The University of Tokyo, Tokyo, 113-0032, Japan.
4
Tochigi-Medical-Center-Shimotsuga, Tochigi, 329-4498, Japan.
5
iMed Japan Inc, Chiba, 275-0001, Japan.
6
Institute of Development, Aging and Cancer, Tohoku University, Miyagi, 980-8575, Japan.
7
Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, 277-8561, Japan.
8
Department of Breast Oncology, Nippon Medical School Hospital, Tokyo, 113-8603, Japan.
9
Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
10
Matrix Cell Research Institute Inc, Ibaraki, 300-1232, Japan.

Abstract

The newly developed radioisotope-free technique based on magnetic nanoparticle detection using a magnetic probe is a promising method for sentinel lymph node biopsy. In this study, a novel handheld magnetic probe with a permanent magnet and magnetic sensor is developed to detect the sentinel lymph nodes in breast cancer patients. An outstanding feature of the probe is the precise positioning of the sensor at the magnetic null point of the magnet, leading to highly sensitive measurements unaffected by the strong ambient magnetic fields of the magnet. Numerical and experimental results show that the longitudinal detection length is approximately 10 mm, for 140 μg of iron. Clinical tests were performed, for the first time, using magnetic and blue dye tracers-without radioisotopes-in breast cancer patients to demonstrate the performance of the probe. The nodes were identified through transcutaneous and ex-vivo measurements, and the iron accumulation in the nodes was quantitatively revealed. These results show that the handheld magnetic probe is useful in sentinel lymph node biopsy and that magnetic techniques are widely being accepted as future standard methods in medical institutions lacking nuclear medicine facilities.

PMID:
29352214
PMCID:
PMC5775278
DOI:
10.1038/s41598-018-19480-1
[Indexed for MEDLINE]
Free PMC Article

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