Format

Send to

Choose Destination
Sci Rep. 2018 Jan 19;8(1):1180. doi: 10.1038/s41598-018-19451-6.

Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma.

Author information

1
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
2
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
3
Virginia Bioinformatics Institute and Department of Statistics, Virginia Tech, Blacksburg, Virginia, USA.
4
Departments of Pathology and Laboratory Medicine, Neurology, and Pharmacology, Lineberger Comprehensive Cancer Center and Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, USA.
5
Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
6
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
7
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
8
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
9
Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA.
10
Wake Forest University Baptist Health Comprehensive Cancer Center, Brain Tumor Center of Excellence, Winston-Salem, North Carolina, USA.
11
Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.
12
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
13
Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, USA.
14
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA. gwoodworth@som.umaryland.edu.
15
Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA. gwoodworth@som.umaryland.edu.

Abstract

Glioma is a unique neoplastic disease that develops exclusively in the central nervous system (CNS) and rarely metastasizes to other tissues. This feature strongly implicates the tumor-host CNS microenvironment in gliomagenesis and tumor progression. We investigated the differences and similarities in glioma biology as conveyed by transcriptomic patterns across four mammalian hosts: rats, mice, dogs, and humans. Given the inherent intra-tumoral molecular heterogeneity of human glioma, we focused this study on tumors with upregulation of the platelet-derived growth factor signaling axis, a common and early alteration in human gliomagenesis. The results reveal core neoplastic alterations in mammalian glioma, as well as unique contributions of the tumor host to neoplastic processes. Notable differences were observed in gene expression patterns as well as related biological pathways and cell populations known to mediate key elements of glioma biology, including angiogenesis, immune evasion, and brain invasion. These data provide new insights regarding mammalian models of human glioma, and how these insights and models relate to our current understanding of the human disease.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center