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Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H839-H852. doi: 10.1152/ajpheart.00409.2017. Epub 2017 Dec 22.

Emerging potential benefits of modulating NAD+ metabolism in cardiovascular disease.

Matasic DS1,2,3, Brenner C3,4, London B1,2,3.

Author information

1
Division of Cardiovascular Medicine, Department of Medicine, University of Iowa , Iowa City, Iowa.
2
Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa , Iowa City, Iowa.
3
Abboud Cardiovascular Research Center, University of Iowa , Iowa City, Iowa.
4
Department of Biochemistry, Carver College of Medicine, University of Iowa , Iowa City, Iowa.

Abstract

Nicotinamide adenine dinucleotide (NAD+) and related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD+ is required for the activity of multifunctional enzymes, including sirtuins and poly(ADP-ribose) polymerases that regulate posttranslational modifications, DNA damage responses, and Ca2+ signaling. Recent research has indicated that NAD+ participates in a multitude of processes dysregulated in cardiovascular diseases. Therefore, supplementation of NAD+ precursors, including nicotinamide riboside that boosts or repletes the NAD+ metabolome, may be cardioprotective. This review examines the molecular physiology and preclinical data with respect to NAD+ precursors in heart failure-related cardiac remodeling, ischemic-reperfusion injury, and arrhythmias. In addition, alternative NAD+-boosting strategies and potential systemic effects of NAD+ supplementation with implications on cardiovascular health and disease are surveyed.

KEYWORDS:

cardiovascular diseases; ischemia-reperfusion; nicotinamide adenine dinucleotide; oxidation-reduction (redox)

PMID:
29351465
PMCID:
PMC5966770
[Available on 2019-04-01]
DOI:
10.1152/ajpheart.00409.2017

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