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Exp Mol Med. 2018 Jan 19;50(1):e428. doi: 10.1038/emm.2017.223.

Critical effects of long non-coding RNA on fibrosis diseases.

Author information

1
Department of Dermatology, 105th Hospital of PLA, Hefei, China.
2
Department of Pathophysiology and High Altitude Pathology, Third Military Medical University, Chongqing, China.
3
Graduate School, Bengbu Medical College, Bengbu, China.
4
Department of Clinical Laboratory, 150th Hospital of PLA, Luoyang, China.
5
Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan, China.
6
Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.

Abstract

The expression or dysfunction of long non-coding RNAs (lncRNAs) is closely related to various hereditary diseases, autoimmune diseases, metabolic diseases and tumors. LncRNAs were also recently recognized as functional regulators of fibrosis, which is a secondary process in many of these diseases and a primary pathology in fibrosis diseases. We review the latest findings on lncRNAs in fibrosis diseases of the liver, myocardium, kidney, lung and peritoneum. We also discuss the potential of disease-related lncRNAs as therapeutic targets for the clinical treatment of human fibrosis diseases.

PMID:
29350677
PMCID:
PMC5799794
DOI:
10.1038/emm.2017.223
[Indexed for MEDLINE]
Free PMC Article

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