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Clin Pharmacol Ther. 2018 Jun;103(6):975-978. doi: 10.1002/cpt.960. Epub 2018 Jan 19.

Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications.

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Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany.
Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Frankfurt am Main, Germany.


The novel research area of functional genomics investigates biochemical, cellular, or physiological properties of gene products with the goal of understanding the relationship between the genome and the phenotype. These developments have made analgesic drug research a data-rich discipline mastered only by making use of parallel developments in computer science, including the establishment of knowledge bases, mining methods for big data, machine-learning, and artificial intelligence, (Table ) which will be exemplarily introduced in the following.

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