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Am J Transplant. 2018 Jul;18(7):1745-1754. doi: 10.1111/ajt.14640. Epub 2018 Jan 25.

Clostridium difficile infection is associated with graft loss in solid organ transplant recipients.

Author information

1
Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
2
Division of Infectious Diseases, Cantonal Hospital Chur, Chur, Switzerland.
3
Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
4
Division of Infectious Diseases & Hospital Hygiene, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
5
Clinic of Internal Medicine & Infectious Diseases, Clinica Luganese, Lugano, Switzerland.
6
Infectious Diseases Service, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
7
Division of Infectious Diseases & Hospital Epidemiology, University Hospital, University of Zürich, Zürich, Switzerland.
8
Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
9
Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zürich, Zürich, Switzerland.
10
Transplant Infectious Diseases Unit, University Hospitals Geneva, Geneva, Switzerland.

Abstract

Clostridium difficile infection (CDI) is a leading cause of infectious diarrhea in solid organ transplant recipients (SOT). We aimed to assess incidence, risk factors, and outcome of CDI within the Swiss Transplant Cohort Study (STCS). We performed a case-control study of SOT recipients in the STCS diagnosed with CDI between May 2008 and August 2013. We matched 2 control subjects per case by age at transplantation, sex, and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors and evaluate outcome of CDI. Two thousand one hundred fifty-eight SOT recipients, comprising 87 cases of CDI and 174 matched controls were included. The overall CDI rate per 10 000 patient days was 0.47 (95% confidence interval ([CI] 0.38-0.58), with the highest rate in lung (1.48, 95% CI 0.93-2.24). In multivariable analysis, proven infections (hazard ratio [HR] 2.82, 95% CI 1.29-6.19) and antibiotic treatments (HR 4.51, 95% CI 2.03-10.0) during the preceding 3 months were independently associated with the development of CDI. Despite mild clinical presentations, recipients acquiring CDI posttransplantation had an increased risk of graft loss (HR 2.24, 95% CI 1.15-4.37; P = .02). These findings may help to improve the management of SOT recipients.

KEYWORDS:

antibiotic: antibacterial; clinical research/practice; complication: infectious; infection and infectious agents - bacterial: Clostridium difficile; infectious disease

PMID:
29349869
DOI:
10.1111/ajt.14640

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