Ameliorative role of camel whey protein and rosuvastatin on induced dyslipidemia in mice

Food Funct. 2018 Feb 21;9(2):1038-1047. doi: 10.1039/c7fo01871a.

Abstract

The incidence of obesity is rapidly increasing throughout the world. Dyslipidemia is a major risk factor for a number of chronic diseases, including diabetes and cardiovascular diseases. This work presents a novel approach to study the activity of camel whey protein (WP) with antioxidant and anti-inflammatory properties as a cheap dietary protein substance extracted from camel milk to produce satiety and help in building muscles. Mice model suffering from dyslipidemia as a result of feeding on high fat-cholesterol diet for 8 weeks were administrated with either camel WP and/or rosuvastatin for 4 weeks. Dyslipidemia revealed significant increase in anthropometrical measurements, levels of glucose, insulin, cholesterol, triglycerides, low-density lipoprotein, total leucocyte count, inflammatory cytokines and reactive oxygen species, accompanied by a significant elevation in activating transcription factor-3 and inducible nitric oxide synthase expressions. These alterations were correlated with a profound reduction in high-density lipoprotein, peroxisome proliferator-activated receptor alpha and adiponectin along with a decrease in liver and muscle mitochondrial proteins. Rosuvastatin treatment to mice suffering from dyslipidemia in combination with camel WP for 4 weeks ameliorated these parameters. Notably, animals treated with both camel WP and rosuvastatin exhibited a remarkable decrease in the incidence of dyslipidemia. In addition, camel WP succeeded to overcome the therapeutic drawback posed from rosuvastatin therapy alone with minimal side effects.

MeSH terms

  • Activating Transcription Factor 3 / genetics
  • Activating Transcription Factor 3 / metabolism
  • Animals
  • Blood Glucose / metabolism
  • Camelus
  • Cholesterol / metabolism
  • Dyslipidemias / drug therapy*
  • Dyslipidemias / genetics
  • Dyslipidemias / metabolism
  • Humans
  • Insulin / metabolism
  • Lipoproteins, LDL / metabolism
  • Male
  • Mice
  • Milk / chemistry
  • Nitric Oxide Synthase Type II / genetics
  • Nitric Oxide Synthase Type II / metabolism
  • Rosuvastatin Calcium / administration & dosage*
  • Triglycerides / metabolism
  • Whey Proteins / administration & dosage*

Substances

  • Activating Transcription Factor 3
  • Blood Glucose
  • Insulin
  • Lipoproteins, LDL
  • Triglycerides
  • Whey Proteins
  • Rosuvastatin Calcium
  • Cholesterol
  • Nitric Oxide Synthase Type II