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Oncotarget. 2017 Oct 20;8(68):113129-113141. doi: 10.18632/oncotarget.21991. eCollection 2017 Dec 22.

Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis.

Author information

1
Department of Emergency Medicine, Guizhou Provincial People's Hospital, Guizhou, China.
2
Department of Oral and Maxillofacial Surgery, Guizhou Provincial People's Hospital, Guizhou, China.
3
Guiyang Hospital of Stomatology, Medical College, Zunyi Medical College, Guiyang, China.
4
Department of Urology, Guizhou Provincial People's Hospital, Guizhou, China.
5
Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, China.
#
Contributed equally

Abstract

Cadmium (Cd) is a pollutant with multiple adverse health effects: cancer, renal dysfunction, osteoporosis and fracture, and cardiovascular disease. Several population-based studies found an association between Cd and diabetes mellitus (DM), but this association is inconsistent with other research. We conducted meta-analysis to examine relationship between urinary/blood Cd exposure and DM risk. Pertinent studies were identified by searching PubMed and Embase databases, and combined odds ratio (OR) and corresponding 95% confidence interval (CI) were applied to evaluate said association. Meta-analysis showed that high U-Cd exposure is not correlated with DM risk (OR = 1.19; 95% CI = 0.83-1.71), and high B-Cd exposure is also not associated with increased risk of DM (OR = 1.16; 95% CI = 0.84-1.62) in the general population. Subgroup and sensitivity analysis proved similar results, with little evidence of publication bias. This meta-analysis suggests that high U-Cd/B-Cd exposure may not be risk factor for DM in general populations. However, large prospective studies are needed to confirm this finding.

KEYWORDS:

cadmium; diabetes mellitus

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no competing financial interests.

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