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Brain Nerve. 2018 Jan;70(1):35-40. doi: 10.11477/mf.1416200947.

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

[Article in Japanese]

Author information

1
Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry.

Abstract

A recent study on the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has revealed an elevation of inflammatory and anti-inflammatory cytokines in the sera and cerebrospinal fluids of the patients and presence of autoantibodies in subgroups of ME/CFS patients. Furthermore, investigator-initiated clinical trials have proved the efficacy of anti-CD20 antibody (rituximab), that eliminate B cells, in the treatment of ME/CFS. Based on these findings, we hypothesize that immune abnormalities, such as enhanced autoimmune responses, may play an essential role in the neuroinflammatory pathogenesis of ME/CFS.

PMID:
29348373
DOI:
10.11477/mf.1416200947
[Indexed for MEDLINE]

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