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Environ Pollut. 2018 Apr;235:850-856. doi: 10.1016/j.envpol.2018.01.016. Epub 2018 Feb 21.

Association between serum arsenic levels and gestational diabetes mellitus: A population-based birth cohort study.

Author information

1
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.
2
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, People's Republic of China.
3
Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, People's Republic of China.
4
Ma'anshan Maternal and Child Health (MCH) Center, Ma'anshan, People's Republic of China.
5
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, People's Republic of China; School of Public Health and Social Work and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia; Shanghai Children's Medical Centre, Shanghai JiaoTong University, Shanghai, People's Republic of China. Electronic address: s.tong@qut.edu.au.
6
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, People's Republic of China. Electronic address: taofangbiao@126.com.

Abstract

Gestational diabetes mellitus (GDM) is a common obstetric complication with adverse effects on both mothers and their children. Previous studies revealed the link between Arsenic (As) exposure and incidence of diabetes mellitus (DM), but the data on the association between maternal As exposure and GDM is scarce. We examined this association among a population-based birth cohort. As concentrations were determined at multiple time points during pregnancy by ICP-MS. The association between As levels and GDM prevalence was examined using logistic regression model after adjustment for confounders. A total of 419 (12.85%) women were diagnosed with GDM. The incidences of GDM gradually increased with increasing quartiles of As levels with significant trend. As levels were associated with the GDM (95%CI: 1.29-2.43) at only the 4th quartile in the first trimester. After adjustment for maternal age, prepregnancy body mass index (BMI), monthly income, gestational age and parity, the association remains significant (95%CI: 1.22-2.38). Stratified analyses showed the associations were largely limited to normal maternal age (95%CI: 1.19-3.04) and normal weight women (95%CI: 1.18-2.66). Our study showed an association between As and GDM in a birth cohort and explored first trimester may be the critical period for As associated GDM. This association was universal in the general pregnant population of normal age and of normal weight.

KEYWORDS:

Arsenic; Birth cohort; Gestational diabetes; Prenatal exposure

PMID:
29348076
DOI:
10.1016/j.envpol.2018.01.016
[Indexed for MEDLINE]

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