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Prog Clin Biol Res. 1985;192:363-70.

Analgesic properties of enkephalinase inhibitors: animal and human studies.

Abstract

D-phenylalanine, bacitracin and puromycin produce long-lasting, naloxone-reversible analgesia in mice. Analgesic potency parallels potency of these compounds as inhibitors of met-enkephalin degradation by mouse brain enzymes. D-phenylalanine potentiates acupuncture analgesia in mice and humans and has been used to ameliorate a variety of human chronic pain conditions.

PMID:
2934746
[Indexed for MEDLINE]

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