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PLoS Biol. 2018 Jan 18;16(1):e2003354. doi: 10.1371/journal.pbio.2003354. eCollection 2018 Jan.

Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1.

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Center for Neural Science, New York University, New York, New York, United States of America.
School of Medicine, New York University, New York, New York, United States of America.
Neuroscience Institute at the New York University Langone Medical Center, New York, New York, United States of America.
Department of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural & Behavioral Science, State University of New York, Downstate Medical Center, Brooklyn, New York, United States of America.


Behavior is used to assess memory and cognitive deficits in animals like Fmr1-null mice that model Fragile X Syndrome, but behavior is a proxy for unknown neural events that define cognitive variables like recollection. We identified an electrophysiological signature of recollection in mouse dorsal Cornu Ammonis 1 (CA1) hippocampus. During a shocked-place avoidance task, slow gamma (SG) (30-50 Hz) dominates mid-frequency gamma (MG) (70-90 Hz) oscillations 2-3 s before successful avoidance, but not failures. Wild-type (WT) but not Fmr1-null mice rapidly adapt to relocating the shock; concurrently, SG/MG maxima (SGdom) decrease in WT but not in cognitively inflexible Fmr1-null mice. During SGdom, putative pyramidal cell ensembles represent distant locations; during place avoidance, these are avoided places. During shock relocation, WT ensembles represent distant locations near the currently correct shock zone, but Fmr1-null ensembles represent the formerly correct zone. These findings indicate that recollection occurs when CA1 SG dominates MG and that accurate recollection of inappropriate memories explains Fmr1-null cognitive inflexibility.

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