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J Funct Biomater. 2018 Jan 18;9(1). pii: E10. doi: 10.3390/jfb9010010.

Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management.

Author information

1
Bioregenerative Medicine and Applied Surgery Research Group, Animal Medicine and Surgery Department, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. debora.chicharro@uchceu.es.
2
García Cugat Foundation for Biomedical Research, 08006 Barcelona, Spain. debora.chicharro@uchceu.es.
3
Bioregenerative Medicine and Applied Surgery Research Group, Animal Medicine and Surgery Department, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. mrubio@uchceu.es.
4
García Cugat Foundation for Biomedical Research, 08006 Barcelona, Spain. mrubio@uchceu.es.
5
Bioregenerative Medicine and Applied Surgery Research Group, Animal Medicine and Surgery Department, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. elena.damia@uchceu.es.
6
García Cugat Foundation for Biomedical Research, 08006 Barcelona, Spain. elena.damia@uchceu.es.
7
Bioregenerative Medicine and Applied Surgery Research Group, Animal Medicine and Surgery Department, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. jcarrill@uchceu.es.
8
García Cugat Foundation for Biomedical Research, 08006 Barcelona, Spain. jcarrill@uchceu.es.
9
Bioregenerative Medicine and Applied Surgery Research Group, Animal Medicine and Surgery Department, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. belen.cuervo@uchceu.es.
10
García Cugat Foundation for Biomedical Research, 08006 Barcelona, Spain. belen.cuervo@uchceu.es.
11
Bioregenerative Medicine and Applied Surgery Research Group, Animal Medicine and Surgery Department, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. pau.pelaez@uch.ceu.es.
12
García Cugat Foundation for Biomedical Research, 08006 Barcelona, Spain. pau.pelaez@uch.ceu.es.
13
Bioregenerative Medicine and Applied Surgery Research Group, Animal Medicine and Surgery Department, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. jsopena@uchceu.es.
14
García Cugat Foundation for Biomedical Research, 08006 Barcelona, Spain. jsopena@uchceu.es.

Abstract

The overall increase of chronic degenerative diseases associated with ageing makes wound care a tremendous socioeconomic burden. Thus, there is a growing need to develop novel wound healing therapies to improve cutaneous wound healing. The use of regenerative therapies is becoming increasingly popular due to the low-invasive procedures needed to apply them. Platelet-rich plasma (PRP) is gaining interest due to its potential to stimulate and accelerate the wound healing process. The cytokines and growth factors forming PRP play a crucial role in the healing process. This article reviews the emerging field of skin wound regenerative therapies with particular emphasis on PRP and the role of growth factors in the wound healing process.

KEYWORDS:

growth factors; platelet-rich plasma; skin; stem cells; wound healing

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