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Helicobacter. 2018 Apr;23(2):e12463. doi: 10.1111/hel.12463. Epub 2018 Jan 18.

Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016.

Author information

1
Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2
Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
3
Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
4
Department of Internal Medicine, Uijongbu St. Mary's Hospital, The Catholic University of Korea, Uijongbu, Korea.
5
Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
6
Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.
7
Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea.
8
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
9
Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
10
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
11
Department of Internal Medicine, Inje University College of Medicine, Busan, Korea.
12
Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
13
Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.
14
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
15
Department of Internal Medicine and Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
16
Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea.
17
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
18
Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
19
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
20
Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
21
Department of Internal Medicine, Gachon Graduated School of Medicine, Gil Medical Center, Incheon, Korea.
22
Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Abstract

BACKGROUND:

The Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables.

METHODS:

We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay.

RESULTS:

We analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P < .0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30-39 years and 57.7% in those aged 40-49 years) and was lower in city residents than in noncity residents at all ages.

CONCLUSIONS:

Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori-related policies.

KEYWORDS:

Helicobacter pylori ; Korea; prevalence

PMID:
29345022
PMCID:
PMC5900911
DOI:
10.1111/hel.12463
[Indexed for MEDLINE]
Free PMC Article

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