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J Tissue Eng. 2018 Jan 9;9:2041731417751286. doi: 10.1177/2041731417751286. eCollection 2018 Jan-Dec.

Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials.

Author information

1
Department of Biomedical Engineering, The City College of New York, New York, NY, USA.
2
Department of Biology, Lehman College, Bronx, NY, USA.
3
Biology, The Graduate Center, The City University of New York, New York, NY, USA.
4
Biochemistry, The Graduate Center, The City University of New York, New York, NY, USA.

Abstract

Strategies to replace retinal photoreceptors lost to damage or disease rely upon the migration of replacement cells transplanted into sub-retinal spaces. A significant obstacle to the advancement of cell transplantation for retinal repair is the limited migration of transplanted cells into host retina. In this work, we examine the adhesion and displacement responses of retinal progenitor cells on extracellular matrix substrates found in retina as well as widely used in the design and preparation of transplantable scaffolds. The data illustrate that retinal progenitor cells exhibit unique adhesive and displacement dynamics in response to poly-l-lysine, fibronectin, laminin, hyaluronic acid, and Matrigel. These findings suggest that transplantable biomaterials can be designed to improve cell integration by incorporating extracellular matrix substrates that affect the migratory behaviors of replacement cells.

KEYWORDS:

Neuroclusters; microfluidics; migration; photoreceptors; transplantation

Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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