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Dis Model Mech. 2018 Jan 17;11(1). pii: dmm031302. doi: 10.1242/dmm.031302.

Growth of human breast cancers in Peromyscus.

Author information

1
Peromyscus Genetic Stock Center, University of South Carolina, SC 29208, USA.
2
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, SC 29208, USA.
3
Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, SC 29208, USA.
4
Peromyscus Genetic Stock Center, University of South Carolina, SC 29208, USA kiarish@sccp.sc.edu.

Abstract

Modeling breast cancer in general and hormone-sensitive breast cancer, in particular in mice, has several limitations. These are related to the inbred nature of laboratory mice, and do not allow adequate appreciation of the contribution of the host's genetic heterogeneity in tumor growth. In addition, the naturally low estrogen levels of mice makes estradiol supplementation obligatory for tumor growth. Here, we show that Peromyscus californicus, following cyclosporine-mediated immunosuppression, supports the growth of both MDA-MB-231 estrogen-independent and MCF7 estrogen receptor-positive breast cancers without exogenous estradiol supplementation. Tumor growth was inhibited by fulvestrant or letrozole, confirming that MCF7 xenografts remain hormone dependent in vivo and suggesting that P. californicus can be used as an alternative to conventional mice for the study of hormone-sensitive breast cancer. The fact that Peromyscus stocks are outbred also facilitates the study of breast cancer in genetically heterogenous populations.

KEYWORDS:

Diversity; Heterogeneity; Mammary cancer; Outbred

PMID:
29343615
PMCID:
PMC5818077
DOI:
10.1242/dmm.031302
[Indexed for MEDLINE]
Free PMC Article

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