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Viruses. 2018 Jan 15;10(1). pii: E37. doi: 10.3390/v10010037.

Structural Insights in Multifunctional Papillomavirus Oncoproteins.

Author information

1
Équipe Labellisée Ligue 2015, Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, 1 rue Laurent Fries, BP 10142, F-67404 Illkirch, France. suarezi@igbmc.fr.
2
Équipe Labellisée Ligue 2015, Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, 1 rue Laurent Fries, BP 10142, F-67404 Illkirch, France. gilles.trave@unistra.fr.

Abstract

Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7 have been recalcitrant to high-resolution structure analysis. However, in the last decade a wealth of three-dimensional information has been gained on both proteins whether free or complexed to host target proteins. Here, we first summarize the diverse activities of these small multifunctional oncoproteins. Next, we review the available structural data and the new insights they provide about the evolution of E6 and E7, their multiple interactions and their functional variability across human papillomavirus (HPV) species.

KEYWORDS:

NMR; X-ray; oncoproteins; papillomaviruses; structure; virus-host interactomics

PMID:
29342959
PMCID:
PMC5795450
DOI:
10.3390/v10010037
[Indexed for MEDLINE]
Free PMC Article

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