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Exp Gerontol. 2018 Mar;103:124-131. doi: 10.1016/j.exger.2018.01.015. Epub 2018 Jan 16.

Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus.

Author information

1
Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, South Korea.
2
Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea.
3
Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea.
4
Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, South Korea.
5
Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea.
6
Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, South Korea.
7
Department of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South Korea.
8
Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, South Korea.
9
Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Wenzhou, Zhejiang 325035, PR China.
10
Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, PR China.
11
Department of Emergency Medicine, Seoul Hospital, College of Medicine, Sooncheonhyang University, Seoul 04401, South Korea.
12
Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea. Electronic address: mhwon@kangwon.ac.kr.
13
Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, South Korea. Electronic address: sychoi@hallym.ac.kr.

Abstract

Exercise improves cognitive impairments induced by transient cerebral ischemia, and modulates synaptic adhesion molecules. In this study, we investigated effects of long-term treadmill exercise on cognitive impairments and its relation to changes of synaptic cell adhesion molecule (SynCAM) 1/2/3 in the hippocampus after 5 min of transient cerebral ischemia in aged gerbils. Animals were assigned to sedentary and exercised groups, given treadmill exercise for 4 consecutive weeks from 5 days after transient ischemia, and evaluated cognitive function through passive avoidance test and Morris water maze test. SynCAM 2 protein levels were determined in the hippocampus by western blot. In addition, neuronal and synaptic changes were examined by NeuN immunohistochemistry, and SynCAM 1/2/3 and MAP2 double immunofluorescence, respectively. We found that transient cerebral ischemia led to neuronal death in the CA1 area and dentate gyrus, and impaired -memory function; however, 4 weeks of treadmill exercise improved ischemia-induced memory impairment. In addition, SynCAM 1/2/3 and SynCAM 2 expression in the hippocampus was significantly decreased in the sedentary group after transient cerebral ischemia; however, SynCAM 1/2/3 expressionand and SynCAM 2 protein level was significantly increased in the ischemic group with exercise. These results suggest that long-term treadmill exercise improves memory impairment through the restoration of decreased SynCAM 1/2/3 expression in the hippocampus induced by transient cerebral ischemia in the aged gerbil.

KEYWORDS:

Aging; Cerebral ischemia; Learning and memory; Rehabilitation; Synaptic adhesion molecules; Treadmill exercise

PMID:
29341891
DOI:
10.1016/j.exger.2018.01.015
[Indexed for MEDLINE]

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