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Methods Mol Biol. 2018;1718:59-70. doi: 10.1007/978-1-4939-7531-0_4.

Preclinical Arterial Spin Labeling Measurement of Cerebral Blood Flow.

Author information

1
Department of Ophthalmology, Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. muire@uthscsa.edu.

Abstract

Magnetic resonance imaging has been utilized as a quantitative and noninvasive method to image blood flow. Arterial spin labeling (ASL) is an MRI technique that images blood flow using arterial blood water as an endogenous tracer. Herein we describe the use of ASL to measure cerebral blood flow completely noninvasively in rodents, including methods, analysis, and important considerations when utilizing this technique.

KEYWORDS:

Arterial spin labeling; Blood flow; Cerebral blood flow; Magnetic resonance imaging; Perfusion; Rodent

PMID:
29341002
DOI:
10.1007/978-1-4939-7531-0_4
[Indexed for MEDLINE]

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