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J Cell Biol. 2018 Feb 5;217(2):445-446. doi: 10.1083/jcb.201712007. Epub 2018 Jan 16.

Rewired Notch/p53 by Numb'ing Mdm2.

Author information

1
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA hkim@sbpdiscovery.org.
2
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA zeev@ronailab.net.
3
Technion Integrated Cancer Center, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.

Abstract

Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53-Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709092) reveal an unexpected role of a newly characterized Numb splice variant in the regulation of p53, which may have significant implications for therapeutic intervention in breast cancer.

PMID:
29339436
PMCID:
PMC5800819
DOI:
10.1083/jcb.201712007
[Indexed for MEDLINE]
Free PMC Article

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