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Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02377-17. doi: 10.1128/AAC.02377-17. Print 2018 Apr.

In Vitro Susceptibility of Neisseria gonorrhoeae Strains to Mupirocin, an Antibiotic Reformulated for Parenteral Administration in Nanoliposomes.

Author information

1
Laboratory of Membrane and Liposome Research, Department of Biochemistry, IMRIC, The Hebrew University, Hadassah Medical School, Jerusalem, Israel ahuva.cern@mail.huji.ac.il.
2
Department of Microbiology and Immunology, F. Edward Hèbert School of Medicine, Uniformed Services University, Bethesda, Maryland, USA.
3
Laboratory of Membrane and Liposome Research, Department of Biochemistry, IMRIC, The Hebrew University, Hadassah Medical School, Jerusalem, Israel.

Abstract

Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94 N. gonorrhoeae strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae.

KEYWORDS:

Nano-mupirocin; antibiotic resistance; antimicrobial activity; antimicrobial resistance; cross-resistance; liposomes

PMID:
29339382
PMCID:
PMC5913977
DOI:
10.1128/AAC.02377-17
[Indexed for MEDLINE]
Free PMC Article

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