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Environ Int. 2018 Apr;113:300-305. doi: 10.1016/j.envint.2018.01.001. Epub 2018 Jan 17.

Relation between cadmium exposure and gestational diabetes mellitus.

Author information

1
Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
2
Wuhan Medical and Health Center for Women and Children, Wuhan, Hubei, People's Republic of China.
3
College of Health Sclence Nursing, School of Wuhan Polytechnic University, Wuhan, Hubei, People's Republic of China.
4
Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address: liyuanyuan@hust.edu.cn.

Abstract

BACKGROUND:

Cadmium (Cd) has been associated with type 2 diabetes in general population. However, the role of Cd in the occurrence of Gestational diabetes mellitus (GDM) remains unclear.

OBJECTIVES:

Our study was aimed at investigating whether Cd exposure during pregnancy was associated with increased risk of GDM.

METHODS:

Cd concentrations were measured in urine samples from 6837 pregnant women in Wuhan, China, from 2012 to 2014. A "modified Poisson" model with a robust error variance was used to examine the association of GDM with continuous natural logarithm (ln) transformed urinary Cd or quartiles of urinary Cd levels.

RESULTS:

For about 3-fold increase in Cd concentrations, there were 16% [relative risk (RR) =1.16; 95% confidence interval (CI): 1.03, 1.33] increase in risk of GDM. Compared with women in the lowest quartile of urinary Cd levels, women in the highest quartile had 1.30 higher risk of GDM [95% CI: 1.05, 1.61; p-trend <0.05]. Further analyses indicated overweight/obese women with higher urinary Cd levels had significantly higher risk of GDM, compared with women in the reference category of lowest quartile of Cd and normal pre-pregnancy body mass index [RR =2.71; 95% CI: 1.81, 4.07].

CONCLUSIONS:

Our study presented a significantly positive association between urinary Cd levels and risk of GDM, supporting the hypothesis that environmental exposure to Cd may contribute to the development of GDM.

KEYWORDS:

Cadmium exposure; Gestational diabetes mellitus; Pregnant women

PMID:
29338949
DOI:
10.1016/j.envint.2018.01.001
[Indexed for MEDLINE]

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