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Semin Perinatol. 2018 Mar;42(2):96-103. doi: 10.1053/j.semperi.2017.12.005. Epub 2018 Jan 12.

Extracorporeal membrane oxygenation in infants with congenital diaphragmatic hernia.

Author information

1
Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Children's Hospital Colorado, 13121 E 17th Ave, MS 8402, Aurora, CO, 80045. Electronic address: Theresa.grover@childrenscolorado.org.
2
Department of Pediatrics, Division of Neonatology, University of Pennsylvania Perelman School of Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
3
Department of Surgery, University of Pennsylvania Perelman School of Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.

Abstract

Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly which impairs normal pulmonary development leading to acute and chronic respiratory failure, pulmonary hypoplasia, pulmonary hypertension, and mortality. CDH is the most common non-cardiac indication for neonatal ECMO. Prenatal and postnatal predictors of CDH severity aid in patient selection. Centers vary in preferred mode of ECMO and timing of CDH repair. Survivors of severe CDH with ECMO are at risk for long-term sequelae including neurodevelopmental delays.

KEYWORDS:

CDH; Neonatal ECMO; Pulmonary hypertension

PMID:
29338874
DOI:
10.1053/j.semperi.2017.12.005
[Indexed for MEDLINE]

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