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PLoS One. 2018 Jan 16;13(1):e0191060. doi: 10.1371/journal.pone.0191060. eCollection 2018.

Exercise-induced circulating microRNA changes in athletes in various training scenarios.

Author information

1
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, Czech Republic.
2
Research Centre for Toxic Compounds in the Environment, Masaryk University, Kamenice 5, Brno, Czech Republic.
3
Department of Athletics, Swimming and Outdoor Sports, Faculty of Sports Studies, Masaryk University, Kamenice 5, Brno, Czech Republic.
4
Central European Institute of Technology, Masaryk University, Kamenice 5, Brno, Czech Republic.

Abstract

BACKGROUND:

The aim of the study was to compare selected extracellular miRNA levels (miR-16, miR-21, miR-93 and miR-222 with the response to 8-week-long explosive strength training (EXPL), hypertrophic strength training (HYP) and high-intensity interval training (HIIT).

METHODS:

30 young male athletes of white European origin (mean age: 22.5 ± 4.06 years) recruited at the Faculty of Sports Studies of Masaryk University were enrolled in this study. The study participants were randomly assigned to three possible training scenarios: EXPL, HYP or HITT and participated in 8-week-long program in given arm. Blood plasma samples were collected at the baseline and at week 5 and 8 and anthropometric and physical activity parameters were measured. Pre- and post-intervention characteristics were compared and participants were further evaluated as responders (RES) or non-responders (NRES). RES/NRES status was established for the following characteristics: 300°/s right leg extension (t300), 60°/s right leg extension (t60), isometric extension (IE), vertical jump, isometric extension of the right leg and body fat percentage (BFP).

RESULTS:

No differences in miRNA levels were apparent between the intervention groups at baseline. No statistically significant prediction role was observed using crude univariate stepwise regression model analysis where RES/NRES status for t300, t60, IE, vertical jump and pFM was used as a dependent variable and miR-21, miR-222, miR-16 and miR-93 levels at baseline were used as independent variables. The baseline levels of miR-93 expressed an independent prediction role for responder status based on isometric extension of the right leg (beta estimate 0.76, 95% CI: -0.01; 1.53, p = 0.052).

DISCUSSION:

The results of the study indicate that 8-week-long explosive strength training, hypertrophic strength training and high-intensity interval training regimens are associated with significant changes in miR-16, mir-21, miR-222 and miR-93 levels compared to a baseline in athletic young men.

PMID:
29338015
PMCID:
PMC5770042
DOI:
10.1371/journal.pone.0191060
[Indexed for MEDLINE]
Free PMC Article

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