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Trends Genet. 2018 Apr;34(4):257-269. doi: 10.1016/j.tig.2017.12.014. Epub 2018 Jan 11.

Defining B Cell Chromatin: Lessons from EBF1.

Author information

1
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
2
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Electronic address: grosschedl@ie-freiburg.mpg.de.

Abstract

Hematopoiesis is regulated by signals from the microenvironment, transcription factor networks, and changes of the epigenetic landscape. Transcription factors interact with and shape chromatin to allow for lineage- and cell type-specific changes in gene expression. During B lymphopoiesis, epigenetic regulation is observed in multilineage progenitors in which a specific chromatin context is established, at the onset of the B cell differentiation when early B cell factor 1 (EBF1) induces lineage-specific changes in chromatin, during V(D)J recombination and after antigen-driven activation of B cells and terminal differentiation. In this review, we discuss the epigenetic changes underlying B cell differentiation, focusing on the role of transcription factor EBF1 in B cell lineage priming.

KEYWORDS:

B cell differentiation; Early B cell factor 1; chromatin; transcription factor network

PMID:
29336845
DOI:
10.1016/j.tig.2017.12.014
[Indexed for MEDLINE]

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