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Fetal Pediatr Pathol. 2018 Feb;37(1):74-83. doi: 10.1080/15513815.2017.1405468. Epub 2018 Jan 16.

Association of REL Polymorphism with Cow's Milk Proteins Allergy in Pediatric Algerian Population.

Author information

1
a Laboratoire de Génétique Moléculaire et Cellulaire , Université des Sciences et de la Technologie d'Oran-Mohamed Boudiaf -USTOMB- , Oran , Algérie.
2
b Département de génétique moléculaire appliquée , Faculté des Sciences et de la vie, Université des Sciences et de a Technologie d'Oran-Mohamed Boudiaf -USTOMB- , Oran , Algérie.
3
c Laboratoire de Physiologie de la Nutrition et Sécurité Alimentaire, Universitéd'Oran 1 Ahmed Benbella , Oran , Algérie.
4
d Departement des maladies infectieuses, EHS Boukhroufa Abdelkader, Canastel , Oran , Algérie.

Abstract

INTRODUCTION:

Cow's milk proteins allergy (CMPA) pathogenesis involves complex immunological mechanisms with the participation of several cells and molecules involved in food allergy. The association of polymorphisms in the interleukin 4, Forkhead box P3 and the avian reticuloendotheliosis genes was investigated in an infant population with CMPA of Western Algeria.

MATERIALS AND METHODS:

We obtained DNA and clinical data from milk allergic subjects during active phase and from a group of non-atopic control subjects.

RESULTS:

Our findings showed that the allele G of the cRel gene intronic polymorphism at +7883 positions was significantly higher among cow's milk proteins allergic patients compared to control subjects.

CONCLUSION:

The results of this study suggest a possible association of CMPA with cRel G+7883T polymorphism.

KEYWORDS:

Cow's milk proteins allergy; FoxP3; IL4; REL; polymorphisms

PMID:
29336650
DOI:
10.1080/15513815.2017.1405468
[Indexed for MEDLINE]

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