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AIDS Care. 2018 Jun;30(6):727-733. doi: 10.1080/09540121.2018.1425363. Epub 2018 Jan 16.

Adherence to antiretroviral therapy, stigma and behavioral risk factors in HIV-infected adolescents in Asia.

Author information

1
a The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT) , The Thai Red Cross AIDS Research Centre , Bangkok , Thailand.
2
b TREAT Asia/amfAR-The Foundation for AIDS Research , Bangkok , Thailand.
3
c Faculty of Medicine , Srinagarind Hospital, Khon Kaen University , Khon Kaen , Thailand.
4
d Chiangrai Prachanukroh Hospital , Chiang Rai , Thailand.
5
e Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.
6
f Children's Hospital 1, Ho Chi Minh City , Vietnam.
7
g National Hospital of Pediatrics , Hanoi , Vietnam.
8
h Pediatric Institute , Hospital Kuala Lumpur , Kuala Lumpur , Malaysia.
9
i Hospital Raja Perempuan Zainab II , Kelantan , Malaysia.
10
j Hospital Likas , Kota Kinabalu , Malaysia.
11
k US Military HIV Research Program , Walter Reed Army Institute of Research , Silver Spring , USA.
12
l Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda , USA.
13
m SEARCH, The Thai Red Cross AIDS Research Centre , Bangkok , Thailand.
14
n University of Amsterdam , Amsterdam , the Netherlands.
15
o Dreamlopments LTD , Bangkok , Thailand.

Abstract

We studied behavioral risks among HIV-infected and uninfected adolescents using an audio computer-assisted self-interview. A prospective cohort study was initiated between 2013 and 2014 in Malaysia, Thailand, and Vietnam. HIV-infected adolescents were matched to uninfected adolescents (4:1) by sex and age group (12-14 and 15-18 years). We enrolled 250 HIV-infected (48% male; median age 14.5 years; 93% perinatally infected) and 59 uninfected (51% male; median age 14.1 years) adolescents. At enrollment, HIV-infected adolescents were on antiretroviral therapy (ART) for a median (IQR) of 7.5 (4.7-10.2) years, and 14% had HIV-RNA >1000 copies/mL; 19% reported adherence <80%. Eighty-four (34%) HIV-infected and 26 (44%) uninfected adolescents reported having ever smoked cigarettes or drunk alcohol (p = 0.13); 10% of HIV-infected and 17% of uninfected adolescents reported having initiated sexual activity; 6 of the HIV-infected adolescents had HIV-RNA >1000 copies/mL. Risk behaviors were common among adolescents, with few differences between those with and without HIV.

KEYWORDS:

Asia; HIV; adherence; adolescents; stigma

PMID:
29336591
PMCID:
PMC5912939
[Available on 2019-06-01]
DOI:
10.1080/09540121.2018.1425363

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