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Allergy. 2018 Jul;73(7):1393-1414. doi: 10.1111/all.13397.

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria.

Author information

1
Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy-Centre-Charité, Berlin, Germany.
2
Department of Dermatology, Medical University of Graz, Graz, Austria.
3
Department of Allergology, Clinica San Carlo, Paderno Dugnano, MI, Italy.
4
Allergy& Immunology Centre, Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
5
Baker Allergy Asthma and Dermatology Clinic, Portland, OR, USA.
6
Allergy Unit, Department of Dermatology, University Hospital, Zürich, Switzerland.
7
University of Cincinnati Physicians Immunology Research Center, Cincinnati, OH, USA.
8
Department of Dermatology and Allergy Centre, Odense University Hospital and University of Southern Denmark, Odense, Denmark.
9
Department of Internal Diseases, Allergology and Clinical Immunology in Katowice, Medical University of Silesia, Katowice, Poland.
10
Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil.
11
Personalized Medicine Asthma and Allergy Clinic-Humanitas University & Research Hospital, Milano, Italy.
12
Department of Medicine and Pediatrics, Penn State University, Hershey Medical Center, Hershey, PA, USA.
13
National Research Center-Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia.
14
Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Division of Evidence Based Medicine, Department of Dermatology, Berlin, Germany.
15
Federal University of Sao Paulo, Sao Paulo, Brazil.
16
Hospital del Mar, IMIM, Universitat Autònoma Barcelona, Barcelona, Spain.
17
Department of Dermatology, Dr. D. Y. Patil Medical College & Hospital, Nerul, Navi Mumbai, India.
18
Clinic of Dermatology, Faculty of Medicine and University Hospital, Coimbra, Portugal.
19
St John's' Institute of Dermatology, Guy's' and St. Thomas' Hospital, NHS Foundation Trust, London, UK.
20
Service d'allergie, Centre Hospitalier Université Laval/Centre Hospitalier Universitaire de Québec, Québec, QC, Canada.
21
Department of Dermatology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
22
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC, USA.
23
Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
24
Campbelltown Hospital and Western Sydney University, Sydney, Australia.
25
Department of Dermatology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
26
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
27
Hospital Médica Sur, Mexico City, Mexico.
28
Royal Free Hospital, London, UK.
29
Department of Dermatology and Allergy, University Hospital of Tenon, Paris, France.
30
Department of Clinical Immunology and Allergy, Smolensk State Medical University, Smolensk, Russia.
31
Scuola e Cattedra di Allergologia e Immunologia Clinica, Dipartimento dell'Emergenza e dei Trapianti d'Organo, Università di Bari, Bari, Italy.
32
University of Groningen, Groningen, The Netherlands.
33
Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA.
34
Allergy and Clinical Immunology Department, Centro Médico-Docente La Trinidad, Caracas, Venezuela.
35
Department of Dermatology, University Medical Center Mainz, Mainz, Germany.
36
Division of Allergy and Clinical Immunology, University of Toronto, Toronto, ON, Canada.
37
Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
38
Dermatology and Venereology Private Practice, Bari and Barletta, Italy.
39
Department of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark.
40
Department of Dermatology and Venereology, Peking University, First Hospital, Beijing, China.

Abstract

This evidence- and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on 1 December 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF) and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, presenting with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous urticaria and other chronic forms of urticaria are disabling, impair quality of life and affect performance at work and school. This guideline covers the definition and classification of urticaria, taking into account the recent progress in identifying its causes, eliciting factors and pathomechanisms. In addition, it outlines evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.

KEYWORDS:

angioedema; consensus; evidence-based; hives; wheal

PMID:
29336054
DOI:
10.1111/all.13397
[Indexed for MEDLINE]

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