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Arch Gynecol Obstet. 2018 Mar;297(3):725-730. doi: 10.1007/s00404-018-4650-7. Epub 2018 Jan 15.

Association of endogenous circulating sex steroids and condition-specific quality of life domains in postmenopausal women with pelvic floor disorders.

Author information

1
Department of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. Barbara.Bodner-Adler@meduniwien.ac.at.
2
Department of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
3
Department of Anesthesiology, Medical University of Vienna, Vienna, Austria.
4
Outcomes Research Consortium, Cleveland, OH, USA.
5
Department of Special Gynecology and Obstetrics, Karl Landsteiner Institute, Vienna, Austria.

Abstract

OBJECTIVE:

To examine the relationship between endogenous sex steroids and various condition-specific quality of life domains in postmenopausal women with pelvic floor disorders. We hypothesized that woman with lowest androgen and estradiol concentrations would report worse scores of quality of life domains.

METHODS:

Forty-six women with pelvic organ prolapse (POP) and 47 cases with stress urinary incontinence (SUI) answered the validated pelvic floor questionnaire and underwent serum sex steroid measurement. A multivariate logistic regression model was used to determine the association between subjective outcome parameters and serum hormonal levels after adjusting for confounders.

RESULTS:

Univariate analysis revealed a strong inverse correlation between serum estradiol level (E2) and prolapse domain score (correlation coefficient = 0.005) as well as a significant positive correlation between SHBG level and prolapse domain score (correlation coefficient = 0.019) in cases with POP. Furthermore, the sex domain score showed a significant negative correlation with the androstendion (correlation coefficient = 0.020), DHEAS (correlation coefficient = 0.046) and testosterone level (correlation coefficient = 0.032) in the POP group. In the multivariate model, high serum SHBG (CI: 0.007-0.046) remained independently associated with worse scores in the prolapse domain and low serum DHEAS (CI: - 0.989 to 1.320) persisted as a significant predictor for a worse score in the sex domain. Regarding SUI cases, no association was noted between serum hormonal levels and quality of life related pelvic floor domains (correlation coefficient > 0.05).

CONCLUSION:

Our results suggest that pelvic floor related quality of life might also be affected by endogenous sex steroids in POP, but not in SUI cases.

KEYWORDS:

Endogenous sex steroids; Health-related quality of life; Pelvic floor questionnaire; Pelvic organ prolapse; Postmenopausal women; Stress urinary incontinence

PMID:
29335782
PMCID:
PMC5808066
DOI:
10.1007/s00404-018-4650-7
[Indexed for MEDLINE]
Free PMC Article

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