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J Agric Food Chem. 2018 Feb 7;66(5):1140-1146. doi: 10.1021/acs.jafc.7b04998. Epub 2018 Jan 30.

Polyoxygenated Cyclohexenoids with Promising α-Glycosidase Inhibitory Activity Produced by Phomopsis sp. YE3250, an Endophytic Fungus Derived from Paeonia delavayi.

Author information

1
School of Chemical Science and Technology, Yunnan University , Kunming 650091, China.
2
Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan Institute of Microbiology, Yunnan University , Kunming 650091, China.
3
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, China.
4
Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, China.

Abstract

Seven new polyoxygenated cyclohexenoids, namely, phomopoxides A-G (1-7), were isolated from the fermentation broth extract of an endophytic fungal strain Phomopsis sp. YE3250 from the medicinal plant Paeonia delavayi Franch. The structures of these compounds were established by spectroscopic interpretation. The absolute configurations of compounds 1 and 4 were confirmed by X-ray crystallographic analysis and chemical derivative approach. All isolated compounds showed weak cytotoxic activities toward three human tumor cell lines (Hela, MCF-7, and NCI-H460) and weak antifungal activities against five pathogenic fungi (Candida albicans, Aspergillus niger, Pyricularia oryzae, Fusarium avenaceum, and Hormodendrum compactum). In addition, compounds 1-7 showed a promising α-glycosidase inhibitory activity with IC50 values of 1.47, 1.55, 1.83, 2.76, 2.88, 3.16, and 2.94 mM, respectively, as compared with a positive control of acarbose (IC50 = 1.22 mM).

KEYWORDS:

Paeonia delavayi; Phomopsis; polyoxygenated cyclohexenoids; α-glucosidase inhibitor

PMID:
29334729
DOI:
10.1021/acs.jafc.7b04998
[Indexed for MEDLINE]

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