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Nat Prod Res. 2019 May;33(10):1423-1430. doi: 10.1080/14786419.2017.1419232. Epub 2018 Jan 15.

Antifungal activity of phenolic monoterpenes and structure-related compounds against plant pathogenic fungi.

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a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan , Yunnan Agricultural University , Kunming , China.


The aim of this work is to explore the possibility of using the phenolic monoterpenes (PMs) as leading compounds with antifungal activity against plant disease. The in vitro antifungal activities of carvacrol and thymol against seven kinds of plant pathogenic fungi were evaluated on mycelium growth rate method, and the results showed that carvacrol and thymol exhibited broad spectrum antifungal activity. Structure requirement for the antifungal activity of PMs was also investigated. The preliminary conclusion was that phenolic hydroxyl and monoterpene were basic structures for the antifungal activity of PMs, and the position of phenolic hydroxyl showed less effect. Ester derivatives of carvacrol and thymol were more effective than carvacrol and thymol against plant pathogenic fungi. We suggested that carvacrol, thymol and their ester derivatives could potentially be used as new fungicide leading compounds.


Antifungal activity; Carvacrol; Phenolic monoterpenes; Structure requirement; Thymol

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