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Neurobiol Aging. 2018 Apr;64:58-67. doi: 10.1016/j.neurobiolaging.2017.12.010. Epub 2017 Dec 20.

Cerebral changes and disrupted gray matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease.

Author information

1
Laboratory of Functional Neuroscience, Pablo de Olavide University, Seville, Spain; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Spain. Electronic address: jlcanlor@upo.es.
2
Laboratory of Functional Neuroscience, Pablo de Olavide University, Seville, Spain; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Spain.
3
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Spain; Service of Neurology, University Hospital "Marques de Valdecilla", University of Cantabria, IDIVAL, Santander, Spain.
4
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Spain; Department of Neurology, Institut d'Investigacions Biomediques Sant Pau-Hospital Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.

Abstract

The diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF samples and performed structural magnetic resonance imaging scans in cognitively normal elderly as part of a cross-sectional multicenter study (SIGNAL project). To identify group differences in cortical thickness, white matter volume, and properties of structural networks, participants were split into controls (N = 20), positive amyloid-β (Aβ1-42+) (N = 19), and positive phosphorylated tau (N = 18). The Aβ1-42+ group exhibited thickening of middle temporal regions, while positive phosphorylated tau individuals showed thinning in the superior parietal and orbitofrontal cortices. Subjects with abnormal CSF biomarkers further showed regional white matter atrophy and more segregated cortical networks, the Aβ1-42+ group showing heightened isolation of cingulate and temporal cortices. Collectively, these findings highlight the relevance of combining structural brain imaging and connectomics for in vivo tracking of Alzheimer's disease lesions in asymptomatic stages.

KEYWORDS:

CSF biomarkers; Cortical thickness; Preclinical Alzheimer's disease; SNAP; Structural cortical networks; White matter

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