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Psychiatry Res. 2018 Mar;261:307-311. doi: 10.1016/j.psychres.2017.12.038. Epub 2017 Dec 15.

Omega-3 supplements reduce self-reported physical aggression in healthy adults.

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LIP/PC2S, University Grenoble Alpes, Grenoble, France.. Electronic address:
Ministry of Security and Justice, Crime, Law Enforcement and Sanctions Research Division (CRS), The Hague, The Netherlands.
LIP/PC2S, University Grenoble Alpes, Grenoble, France.
Center for Mind and Brain, University of California, Davis, United States.
University Hospital, University Grenoble Alpes, Grenoble, France.
MSH Alpes, CNRS/University Grenoble Alpes, Grenoble, France.
School of Communication and Department of Psychology, The Ohio State University, Columbus, Ohio, United States.


There is emerging evidence that Omega-3 polyunsaturated fatty acids (PUFA) supplements can decrease aggression. However, experimental studies with adults from non-specific populations are scarce. We hypothesized that Omega-3 supplements would decrease self-reported aggression among non-clinical participants. In a double-blind randomized trial, two groups of participants (N = 194) aged 18-45 from the general population followed a 6-weeks treatment with 638mg docosahexaenoic acid (DHA) and 772mg eicosapentaenoic acid (EPA) per day or the equivalent quantity of copra oil (placebo). Self-reported aggressiveness was measured at baseline and after the 6-week treatment period. Findings showed that Omega-3 supplements significantly decreased self-reported aggressiveness at the end of the 6-week period (d = 0.31). In conclusion, this experiment indicates that Omega-3 administration has beneficial effects in reducing aggression among the general population.

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