Format

Send to

Choose Destination
Water Res. 2018 Apr 1;132:167-176. doi: 10.1016/j.watres.2017.12.071. Epub 2018 Jan 5.

Identification of the disinfection byproducts of bisphenol S and the disrupting effect on peroxisome proliferator-activated receptor gamma (PPARγ) induced by chlorination.

Author information

1
Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, 100193, China; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, 100013, China.
2
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, 100013, China.
3
College of Urban and Environment Sciences, Peking University, Beijing, 100871, China.
4
Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, 100193, China; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, 100013, China; College of Public Health, Capital Medical University, Beijing, 100069, China. Electronic address: shaobingch@sina.com.

Abstract

Bisphenol S (BPS), an alternative product to bisphenol A (BPA), has been the focus of increasing public concern due to its potential endocrine disrupting effect and its adverse effects related to metabolic disorders such as obesity. The detection of its residue in drinking water supply systems suggests that BPS can be chlorinated; however, whether its endocrine disrupting effect can be disrupted by this chlorination remains unclear. In the present study, we identified the byproducts of the reaction of BPS with chlorine and assessed the effect of the main byproducts on peroxisome proliferator-activated receptor gamma (PPARγ). BPS was chlorinated in a simulation experiment. The chlorination reaction in this study was chlorine and pH dependent, and the pseudo-first-order reaction rate constant was controlled by the chlorine concentration and pH. The reaction rate at pH 8.5 was 7 times faster than that at pH 6.5. Twenty-two byproducts were putatively identified by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-ESI-Q-ToF-MS), and five main byproducts were purified and characterized by 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. The PPARγ effects of the byproducts were assayed, revealing a2-to4-fold enhancement in their activities in comparison with the parent compound.

KEYWORDS:

Bisphenol S; Chlorination; LC-ESI-Q-ToF-MS; PPARγ

PMID:
29331639
DOI:
10.1016/j.watres.2017.12.071
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center