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Infect Control Hosp Epidemiol. 2018 Feb;39(2):226-228. doi: 10.1017/ice.2017.279. Epub 2018 Jan 14.

Institution-wide and Within-Patient Evolution of Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium Bloodstream Infections.

Author information

1
1Department of Internal Medicine,Michigan Medicine,Ann Arbor,Michigan.
2
2Department of Pharmacy,Michigan Medicine,Ann Arbor,Michigan.
3
3Department of Pathology,Michigan Medicine,Ann Arbor,Michigan.
4
4Department of Biology,The Pennsylvania State University,University Park,Pennsylvania.

Abstract

We report daptomycin minimum inhibitory concentrations (MICs) for vancomycin-resistant Enterococcus faecium isolated from bloodstream infections over a 4-year period. The daptomycin MIC increased over time hospital-wide for initial isolates and increased over time within patients, culminating in 40% of patients having daptomycin-nonsusceptible isolates in the final year of the study. Infect Control Hosp Epidemiol 2018;39:226-228.

PMID:
29331166
PMCID:
PMC5854150
DOI:
10.1017/ice.2017.279
[Indexed for MEDLINE]
Free PMC Article

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