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Sci Rep. 2018 Jan 12;8(1):692. doi: 10.1038/s41598-017-19040-z.

The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.

Author information

1
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
2
Department of Psychoanalysis and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
3
Karl Landsteiner University for Health Sciences, University Clinic Tulln, Alter Ziegelweg 10, 3430, Tulln, Austria.
4
Department of Laboratory Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
5
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. alexandra.schosser@meduniwien.ac.at.
6
Zentren für Seelische Gesundheit, BBRZ-Med, Schererstrasse 30, 1210, Vienna, Austria. alexandra.schosser@meduniwien.ac.at.

Abstract

The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to eliminate heterogeneity within the sample by only recruiting affective disorder patients and find associations between COMT polymorphisms and defined suicidal phenotypes. In a sample of 258 affective disorder patients a detailed clinical assessment (e.g. CTQ, SCAN, HAMD, SBQ-R, VI-SURIAS, LPC) was performed. DNA of peripheral blood samples was genotyped using TaqMan® SNP Genotyping Assays. We observed that the haplotype GAT of rs737865, rs6269, rs4633 is significantly associated with suicide attempt (p = 0.003 [pcorr = 0.021]), and that there is a tendency towards self-harming behaviour (p = 0.02 [pcorr = 0.08]) and also NSSI (p = 0.03 [pcorr = 0.08]), though the p values did not resist multiple testing correction. The same effect we observed with the 4-marker slide window haplotype, GATA of rs737865, rs6269, rs4633, rs4680 (p = 0.009 [pcorr = 0.045]). The findings support an association between the COMT gene and suicidal behaviour phenotypes with and without childhood maltreatment as environmental factor.

PMID:
29330410
PMCID:
PMC5766555
DOI:
10.1038/s41598-017-19040-z
[Indexed for MEDLINE]
Free PMC Article

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