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Semin Cell Dev Biol. 2018 Oct;82:79-85. doi: 10.1016/j.semcdb.2018.01.002. Epub 2018 Jan 12.

A primer on caspase mechanisms.

Author information

1
Graduate Program in Biomedical Sciences, NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
2
Graduate Program in Biomedical Sciences, NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: gsalvesen@sbpdiscovery.org.

Abstract

Caspases belong to a diverse clan of proteolytic enzymes known as clan CD with highly disparate functions in cell signaling. The caspase members of this clan are only found in animals, and most of them orchestrate the demise of cells by the highly distinct regulated cell death phenotypes known as apoptosis and pyroptosis. This review looks at the mechanistic distinctions between the activity and activation mechanisms of mammalian caspases compared to other members of clan CD. We also compare and contrast the role of different caspase family members that program anti-inflammatory and pro-inflammatory cell death pathways.

KEYWORDS:

Apoptosis; Gasdermin; Protease; Pyroptosis; Regulated cell death

PMID:
29329946
PMCID:
PMC6043420
DOI:
10.1016/j.semcdb.2018.01.002
[Indexed for MEDLINE]
Free PMC Article

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